4:00pm
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5:00pm |
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iGOT Neuroprotection
(VTC)
Cameron Rink, PhD
Assistant Professor
Division of Vascular Diseases and Surgery
Department of Surgery
Davis Heart and Lung Research Institute
The Ohio State University Wexner Medical Center
Glutamate serves multifaceted (patho)physiological functions in the central nervous system as the most abundant excitatory neurotransmitter and under pathological conditions as a potent neurotoxin. Regarding the latter, elevated extracellular glutamate is known to play a central role in ischemic brain injury. This work stems from a key observation demonstrating that induction of glutamate oxaloacetate transaminase (iGOT), a glutamate metabolizing enzyme in the brain, can attenuate stroke-induced injury. The energy demands of the brain are among the highest of all organs, underscoring the need to quickly mobilize alternative carbon skeletons for metabolism in the absence of glucose during ischemic stroke. Dr. Rink will discuss the central hypothesis that iGOT can use otherwise neurotoxic glutamate to support survival of glucose-starved neural tissue during ischemia.
Hosted by: Michael J. Friedlander, PhD, Executive Director, Virginia Tech Carilion Research Institute
More information...
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540-526-2070