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Targeting Arteriogenesis in Acute Ischemic Stroke
(VTC)
Cameron Rink, PhD
Assistant Professor
Division of Vascular Diseases and Surgery
Department of Surgery
Davis Heart and Lung Research Institute
The Ohio State University Wexner Medical Center
Arteriogenesis refers to the growth of a functional collateral blood supply. In the brain, cerebrovascular collaterals form networks of anastomosing arterioles that are clinically documented to perfuse stroke-affected tissue during cerebral ischemia and attenuate brain injury. While strategies that target arteriogenesis against ischemic stroke are of significant clinical interest, mechanisms and a means to improve cerebrovascular collateral circulation remain unknown. Dr. Rink will discuss work that leverages a key in vivo observation that a natural vitamin E analog (tocotrienol) improves cerebrovascular collateral circulation to study mechanisms of arteriogenic remodeling for protection against stroke.
Live Webcast: http://research.vtc.vt.edu/live-webcast
Hosted by: Michael J. Friedlander, PhD, Executive Director, Virginia Tech Carilion Research Institute
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540-526-2070